To be secreted, extracellular proteins must cross a membrane from inside the cell to the outside. They make this journey via a single channel called the secretory translocon.
Molecular Gates bind to the secretory translocon and set up a “gate” that recognizes and blocks a specific, disease-causing protein from passing through. Other, non-targeted proteins are able to move through the channel normally.
With nowhere to go, the blocked protein is degraded instead of secreted. This leads to the elimination of the disease-causing protein.
Our science is fueled by our Molecular Gate Discovery Platform™, which combines our privileged library of Molecular Gates, suite of bespoke secretion-focused assays and technologies, and deep expertise into the biology of the secretory pathway. Our platform enables precise, rapid, and repeatable drug discovery. And it gets stronger with every Molecular Gate program.
